Post-Translational Modification Biology of Glutamate Receptors and Drug Addiction
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چکیده
منابع مشابه
Post-Translational Modification Biology of Glutamate Receptors and Drug Addiction
Post-translational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active phosphorylation at serine, threonine, or tyrosine residues in their intracellular domains. Recent evidence identifies several glutamate receptor subtypes t...
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Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...
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Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
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Bioinformatics is an applied science, and its focus of attention is inevitably a moving target. The initial focus was upon the sequence, structure, function and evolution of (almost always) individual nucleic acids or proteins. However, much more attention is now being paid to populations of molecules, or the interactions between molecules that underpin higher-order organisation (anatomy) or pr...
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ژورنال
عنوان ژورنال: Frontiers in Neuroanatomy
سال: 2011
ISSN: 1662-5129
DOI: 10.3389/fnana.2011.00019